Use of a New Ziprasidone-Selective Electrode in Mixed Solvents and Its Application in the Analysis of Pharmaceuticals and Biological Fluids
نویسندگان
چکیده
The construction and characterization of a new ion-selective electrode for the determination of the antipsychotic ziprasidone in mixed solvents is presented. The electrode contains a plasticized polymeric membrane based on a ziprasidone-tetraphenylborate ion-exchanger. The influence of membrane composition on the electrode response towards ziprasidone in hydroalcoholic solutions was studied. The electrode displayed a stable response in a 2:3 (v/v) methanol/water medium from a ziprasidone concentration of 3 × 10(-6) M with a fast response time of less than 20 s. The electrode also showed good selectivity towards ziprasidone over common inorganic and organic compounds and several species with pharmacological activity. The electrode was successfully applied to the determination of ziprasidone in pharmaceuticals and human urine and serum.
منابع مشابه
Design and Fabrication of PVC Membrane Electrode Based on Netural Ligand (E)-N'-(1-(2-Hydroxyphenyl)Ethylidene)Benzohydrazi for Teramadol hydrochloride Measurement in Drugs and Biological Fluids
Here, a simple, quick, Low cost and sensitive Potentiometric method is described for tramadol hydrochloride measurement using .PVC membrane electrode based on neutral ligand (E)-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazid. Besides, effect of various parameters like ionic additives, membrane solvent and pH on the Potentiometric response of the electrode are investigated. The best electrode p...
متن کاملDetermination of Cobalt(II) by a New PVC Membrane Coated Graphite Electrode Based on 6-chloro-11- azabenzo[a]phenothiazin-5-one as a neutral ion carrier
Cobalt has great biological effects on human beings and also other living organisms, hence its determination is very important. In this regard, a novel coated graphite electrode was designed for determination of Co2+ ions by exploiting 6-chloro-11- azabenzo[a]phenothiazin-5-one as a neutral ion carrier, for the first time. The foremost function was witnessed from the membrane composition of PVC...
متن کاملDesign and Optimization of a New Voltammetric Method for Determination of Isoniazid by Using PEDOT Modified Gold Electrode in Pharmaceuticals
Isoniazid (INH) was studied with regard to its electrochemical treatment on a strongly alkaline solution of a poly (3,4-ethylenedioxythiophene)-modified gold electrode, using both cyclic voltammetry and controlled potential techniques. This composite electrode exhibited 4-fold higher oxidation of INH, in accordance with peak densities, than the bare gold electrode. It was used the central compo...
متن کاملFabrication of Nano Poly Cresol Red over Glassy Carbon Electrode and its Application in Selective Determination of Uric acid in the Presence of Ascorbic Acid
A selective electrochemical method for the determination of uric acid was developed by using nano poly cresol red modified glassy carbon electrode. This new material has been characterized by Scanning Electron Microscopy, cyclic voltammetry and Differential pulse voltammetry. This modified electrode shows excellent electrocatalytic activity towards the oxidation of uric acid in the presence of ...
متن کاملHighly Selective Perchlorate Membrane Electrode Based on Synthesized Schiff Base Complex
In this work we introduce a practical use of synthesized Schiff base metal complex in sensing application. A new perchlorate-selective electrode based on the complex N, N'-4-nitro-phenylmethanebis-(salicylaldiminato) copper (II) [CuL] as the membrane carrier was developed. The electrode exhibits a good Nernstian slope of -55.0 ± 1.0 mV/decade and a linear range of for perchlorate. The lim...
متن کامل